PENS (FENS/IBRO) Training Center

Imaging Brain Function: From Behaviour to Diseases

September 9 - 29, 2007 / Lausanne & Geneva, Switzerland

Program

For the first week the program includes lectures, poster sessions and informal discussions.

All of which takes place at the Hotel du Signal de Chexbres.

During the second and third week students perform two short research projects in laboratories of their choice.

Week 1

Sunday September 9th 2007

17:30Welcoming drinks
19:00Dinner

Monday September 10th - Imaging the motor system

09:00-09:30 Program overview
Discussion Leader - Christoph Michel (CMU, Unige, Geneva)
09:30-11:30 Miguel Nicolelis (EPFL, Lausanne)
Multi-site recording in behaving animals.
11:30-12:30Discussion
12:30-14:00Lunch
14:00-16:00Richard Frackowiak (UCL, London, UK)
MRI studies of plasticity and reorganization of motor systems after brain injury.
16:00-17:00Discussion
17:00-17:30Coffee
17:30-18:30 Student Poster Session: posters 1 to 13
18:45-20:00Dinner

Tuesday September 11th - Imaging synapses and neural activity in normal and diseased states

Discussion Leader - Dominique Muller (CMU, Unige, Geneva)
09:30-11:30

Fritjof Helmchen (University of Zurich, Switzerland)
In vivo 2-photon imaging of neural activity. 3D imaging of neural network activity.

11:30-12:30Discussion
12:30-14:00Lunch
14:00-16:00 Wenbiao Gan (New York University, USA)
The cellular basis of neural plasticity. Transgenic mouse models of Alzheimer’s disease.
16:00-17:00Discussion
17:00-17:30Coffee
17:30-18:30 Student Poster Session: posters 14 to 26
18:45-20:00 Dinner

Wednesday September 12th - Imaging higher brain functions

Discussion Leader - Pierre Magistretti (BMI, EPFL and CNP, Lausanne)
09:30-11:30 Denis Le Bihan  (Institut de France, Paris)
The role of water in functional neuroimaging
11:30-12:30Discussion
12:30-14:00Lunch
14:00-15:00 Christoph Michel (CMU, University of Geneva)
EEG/MEG in modern cognitive/clinical neuroscience.
15:00-15:30 Coffee
15:30-16:30 Riitta Salmelin (Helsinki University of Technology, Finland)
EEG/MEG in modern cognitive/clinical neuroscience
16:30-17:30 Discussion
19:00-20:30 Dinner

Thursday September 13th - Reward processing in the brain

Discussion Leader - Carl Petersen (BMI, EPFL, Lausanne)
09:30-11:30 Wolfram Schultz  (Cambridge, UK)
Motivational and cognitive mechanisms underlying goal-directed behaviour.
11:30-12:30Discussion
12:30-14:00Lunch
14:00-15:00 Christian Luscher (CMU, University of Geneva)
Cellular mechanisms of drug reinforcement, dependence and addiction.
15:00-15:30 Coffee
15:30-16:30 Andreas Lüthi (Biozentrum, Basel University, Switzerland)
Synaptic mechanisms of learning and memory. Study of amygdala function and dysfunction in vivo.
16:30-17:30 Discussion
19:00-20:30 Dinner

Friday September 14th - Autism / General discussion

Discussion Leader - Egbert Welker (DBCM, Univ. of Lausanne)
9:30-11:30Nouchine Hadjikani (BMI, EPFL, Lausanne)

Autism: a Neurodevelopmental Disease.

11:30-12:30Discussion
12:30-14:00Lunch
14:00-16:00 General discussion
16:00 Join the Lemanic Neuroscience Annual Meeting

Weeks 2 & 3

Students will perform two experimental projects, one each week, choosing from a total of 26 projects (PDF ) offered by the following 23 laboratories:

Number Name Institution Project Title Techniques / Notes Related Articles
1 Patrick Aebischer

Jean-Charles Bensadoun

Bernard Schneider

Delphine Charvin
BMI, EPFL, Lausanne Therapeutic effects of polyphenols in Amyotrophic Lateral Sclerosis : from behavioural tests to motoneuron analyses. - behavioural tests
- electromyography
- spinal cord slices preparation
- staining and imaging of neuromuscular junctions and spinal motoneurons
2 Paola Bezzi

Jean-Yves Chatton

Graham Knott
DBCM/CIF/CEM, University of Lausanne Imaging synaptic vesicles: structural and functional analysis - Electron microscopy (preparation and imaging)
- Total internal reflection fluorescence (TIRF) microscopy
- Confocal microscopy
- Photoconversion
- Styryl dyes (FM1-43 or 4-64)
- Immunocytochemistry
- Image processing
- 3D image reconstruction.
Steyer & Almers 2001
Zenizek et al. 2000 Darcy et al. 2006
3 Olaf Blanke BMI, EPFL, Lausanne Studying functional and neural interactions between corporeal awareness and self processing using high density electrical neuroimaging. High-Density EEG Blanke et al. 2005
Blanke & Mohr 2005
Arzy et al. 2006
4a Rolf Gruetter

Nathalie Just
STI, EPFL, Lausanne Vessel size index MR imaging at 9.4T   Troprčs et al. 2001
4b Rolf Gruetter

Gunnar Krueger
CH F1 626, EPFL, Lausanne "Resting state" fMRI - fMRI
- Image processing

4c Rolf Gruetter

Carole Poitry-Yamate
IPMC/CIBM/LIFMET, EPFL, Lausanne Quantitation of glucose and glycogen in rat brain:
are there regional differences under varying glycemic conditions?
- absorbance spectrophotometry
- microdissection
- neurochemistry techniques
4d Rolf Gruetter

Wietske van der Zwaag
STI, EPFL, Lausanne Physiological effects in high field MRI fMRI
5 Nouchine Hadjikhani BMI, EPFL, Lausanne Visuo-social cognition in neurodevelopmental disorders fMRI
6 Vicente Ibáńez

Nathalie Ginovart

Philippe Millet

Marcelle Moulin-Sallanon
HUG, Geneva Dopaminergic neurotransmission: Changes in D2 receptors affinity and density under amphetamine challenge. - PET
- Phosphoimager
- ex vivo binding
 
7 Jozsef Kiss

Alexandre Dayer
CMU, Univesity of Geneva Cellular dynamic of neural progenitor cells: analysis of cell migration and neurite outgrowth. - time-lapse video analysis
- imaging of transplanted cells in tissue
- fluorescent and confocal optics
- electron microscopy
Zhang et al. 2003
Zhang et al. 2003
8 Cécile Lebrand DBCM, University of Lausanne Transient GABAergic interneurons are required to guide commissural axons - Organotypic slices
- In vitro focal electroporation method
- Confocal time-lapse video microscopy
- Image processing
 
9 Christian Lüscher CMU, Univesity of Geneva Characterization of the morphology of dopamine neurons in the VTA. Two-Photon confocal line scanning microscope (Olympus Fluoview). Cruz & Lüscher 2005
10 Fulvio Magara University of Lausanne    
11 Pierre Marquet

Pierre Magistretti
BMI, EPFL, Lausanne Study of the neuron-glial dynamics with digital holography microscopy. - Digital holographic microscopy (DHM)
- Video fluorescence microscopy and electrophysiology
Rappaz et al. 2005
Marquet et al. 2005
12 Christoph Michel

Gregor Thut
CMU/HUG, Univesity of Geneva Mapping of brain electric activity by high density scalp and intracranial EEG in man and mice. - High-Resolution (256-channel) scalp EEG and ERP in man
- Multichannel epicranial EEG and EP in mice
- Transcranial magnetic stimulation combined with EEG in man
- Intracranial mutlichannel EEG in epileptic patients
Michel et al. 2004
Michel et al. 2001
13 Dominique Muller CMU, Univesity of Geneva Confocal imaging of synaptic plasticity and turn-over. Slice cultures preparation, biolistic transfection, extracellular recordings, single photon and two-photon imaging of spines, time-lapse imaging.
14 Micah Murray CHUV, Lausanne Multisensory Interactions and Parallel Pathways in Human Sensory-Cognitive Processing. 160 Channel EEG, electrical neuroimaging and psychophysics. De Santis et al. 2006
Murray et al. 2004
Ghazanfar & Schroeder 2006
Murray et al. 2006
15 Carl Petersen BMI, EPFL, Lausanne Two-photon imaging in-vivo In vivo two-photon imaging in anesthetised mice Petersen et al. 2003
Margrie et al. 2003
Tachtenberg et al. 2002
16 Carmen Sandi

Cristina Marquez

Maria Toledo-Rodriguez
LGC, BMI, EPFL, Lausanne Imaging brain metabolism in an animal model of psychopathology - Measuring 14C-2Deoxy-glucose signal in anatomically identified brain regions using the MCID system
- Analyses of behavioural variable
 
17 Françoise Schenk Lausanne      
18 Ralf Schneggenburger BMI, EPFL, Lausanne      
19 Armin Schnider

Stephanie Morand
HUG, Geneva Reorganisation of cognitive functions after brain damage studied with high resolution electrical neuroimaging - High-resolution scalp EEG in healthy subjects and patients
- Behavioural tests
 
20 Sophie Schwartz CMU, Univesity of Geneva Neural plasticity and reactivation of memory traces during sleep as assessed by functional MRI and EEG in humans. Intracranial EEG recordings (in patients), long-term scalp EEG recordings (in normal controls) and fMRI. Stickgold 2005
Peigneux et al. 2004
Huber et al. 2004
Maquet et al. 2000
21 Dimitri van de Ville BIG, EPFL, Lausanne Statistical analysis and classification of fMRI brain data. - MRI acquisition (anatomical and functional)
- Signal & image processing
- Statistical analysis
- Classification techniques
Van De Ville et al. 2006
22 Andrea Volterra

Sabino Vesce
DBCM, University of Lausanne Two-photon in vivo imaging of glial cells In vivo two-photon imaging in anesthetized mice  
23 Patrik Vuilleumier CMU, Univesity of Geneva Functional neuroimaging of cognitive and emotional processing (fMRI & EEG) fMRI, EEG and behavioural tests. Vuilleumier et al. 2004
Vuilleumier et al. 2001
Peelen et al. 2006
Sander et al. 2006
Sander et al. 2006