PENS (FENS/IBRO) Training Center

Imaging Brain Function: From Synapses to Networks

September 7 - 27, 2008 / Lausanne & Geneva, Switzerland

Organizers

Pierre Magistretti

Prof. Pierre Magistretti

Laboratory of Neuroenergetics and Cellular Dynamics

Co-Director, Brain Mind Institute, EPFL

Director, Center for Psychiatric Neuroscience,
Department of Psychiatry, CHUV and University of Lausanne,
Lausanne, Switzerland.

Research:

Cellular and molecular mechanisms of brain energy metabolism.

Technical expertise of the laboratory:

Digital Holographic Microscopy.

Recent publications:

  • Pellerin, L. and Magistretti, P.J. (2004)
    Let there be (NADH) light. SCIENCE 305, 50-52.
  • Marquet, P., Rappaz, B., Magistretti, P.J., Cuche, E., Emery, Y., Colomb, T., Depeursinge, C. (2005)
    Digital holographic microscopy : a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy. OPTICS LETTERS 30 : 468-470.
  • Ros J, Pellerin L, Magara F, Dauguet J, Schenk F, Magistretti PJ.
    Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval. J CEREB BLOOD FLOW METAB. (Advance online publication, 31 August 2005)
  • Agnès Aubert, Robert Costalat, Pierre J. Magistretti and Luc Pellerin (2005)
    Brain lactate kinetics: modeling evidence for neuronal lactate uptake upon activation. Proc. Natl. Acad. Sci. USA 102(45):16448-53
Dominique Muller

Prof. Dominique Muller

Department of Basic Neuroscience,
CMU, University of Geneva,
Switzerland.

Website

Research:

Study of the mechanism underlying the plasticity of excitatory connectios in the brain using hippocampal organotypic slice cultures as a model.

Technical expertise of the laboratory:

whole cell patch-clamp, dual cell recordings, time lapse imaging of synapses using two-photon confocal microscopy, ultrastructural analyses using 3-D EM reconstruction and molecular tools.

Recent publications:

  • Jourdain, P., Fukunaga, K. and Muller, D. (2003)
    Calcium/calmodulin-dependent protein kinase II contributes to activity-dependent filopodia growth and spine formation J. NEUROSCI. 23: 10645-10649.
  • Nikonenko, I., Jourdain P. and Muller, D. (2003)
    Presynaptic remodelling contributes to activity-induced synaptogenesis J. NEUROSCI. 23:8498-505.
  • Boda B., Alberi S., Nikonenko I., Node-Langlois R., Jourdain P., Moosmayer M., Parisi- Jourdain L. and Muller D. (2004)
    The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. J. NEUROSCI. 24:10816-825.
Carl Petersen

Assistant Prof. Carl Petersen

Laboratory of Sensory Processing,
Brain Mind Institute, EPFL,
Lausanne, Switzerland.

Website

Research:

Synaptic mechanisms of sensory perception and associative learning.

Technical expertise of the laboratory:

Voltage-sensitive dye imaging, intrinsic optical imaging, two photon imaging.

Recent publications:

  • Ferezou I, Haiss F, Gentet LJ, Aronoff R, Weber B, Petersen CCH (2007) Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice. Neuron 56: 907-923.
  • Berger T, Borgdorff AJ, Crochet S, Neubauer FB, Lefort S, Fauvet B, Ferezou I, Carleton A, Luscher HR, Petersen CCH (2007) Combined voltage and calcium epifluorescence imaging in vitro and in vivo reveals subthreshold and suprathreshold dynamics of mouse barrel cortex. J Neurophysiol 97: 3751-3762.
  • Ferezou I, Bolea S, Petersen CCH (2006) Visualizing the cortical representation of whisker touch: voltage-sensitive dye imaging in freely moving mice. Neuron 50: 617-629.
Egbert Welker

Prof. Egbert Welker

Department of Cellular and Molecular Biology (DBCM),
University of Lausanne,
Switzerland.

Website

Research:

Study of the mechanisms by which sensory experience shapes cortical circuitry.

Technical expertise of the laboratory:

Ultrastructural analyses using 3-D EM reconstruction.

Recent publications:

  • Croquelois A, Bronchti G, Welker E. (2005)
    Cortical origin of functional recovery in the somatosensory cortex of the adult mouse after thalamic lesion. Eur J Neurosci. 2005 Apr;21(7):1798-806.
  • Di Cristo G, Wu C, Chattopadhyaya B, Ango F, Knott G, Welker E, Svoboda K, Huang ZJ. (2004)
    Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. Nat Neurosci. 2004 Nov;7(11):1184-6. Epub 2004 Oct 10.
  • Genoud C, Knott GW, Sakata K, Lu B, Welker E. (2004)
    Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice. J Neurosci. 2004 Mar 10;24(10):2394-400.