For the first week the program includes lectures, poster sessions and informal discussions.
All of which will take place at the Hotel du Signal de Chexbres.
During the second and third week, students will perform two small research projects in laboratories of their choice.
Week 1
Sunday September 3rd 2006
Monday September 4th - Imaging Molecules
Tuesday September 5th - Imaging Synapses
Wednesday September 6th - Imaging Sensory and Cognitive Processing
Thursday September 7th - Imaging the Human BrainDiscussion Leader - Pierre Magistretti
Friday September 8th - New Techniques
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Weeks 2 & 3
Students will perform two experimental projects, one each week, choosing from a total of 19 projects offered by the following laboratories:
| Name | Institution | Research Project | Techniques and Notes | Related Articles | |
|---|---|---|---|---|---|
| Paola Bezzi Jean-Yves Chatton Graham Knott |
DBCM/CIF/CEM University of Lausanne | Imaging synaptic vesicles: structural and functional analysis | Electron microscopy (preparation and imaging), total internal reflection fluorescence (TIRF) microscopy, confocal microscopy, photoconversion, styryl dyes (FM1-43 or 4-64), immunocytochemistry, image processing, three dimensional image reconstruction. |
Steyer & Almers 2001 Zenizek et al. 2000 Darcy et al. 2006 |
|
| Olaf Blanke | BMI, EPFL, Lausanne | Studying functional and neural interactions between corporeal awareness and self processing using high density electrical neuroimaging. | High-Density EEG. | Blanke et al. 2005 Blanke & Mohr 2005 Arzy et al. 2006 |
|
| Alan Carleton | BMI, EPFL, Lausanne | 1. Study of the spatiotemporal dynamics of odor-evoked activity in the mouse olfactory bulb. 2. Imaging of migration and differentiation of adult-born neurons. |
1. In vivo intrinsic and/or voltage-sensitive dye imaging in anesthetised mice. 2. In vitro two-photon imaging in slices. |
1. Abraham et al. 2004 2. Carleton et al. 2003 |
|
| Christian Depeursinge | STI, EPFL, Lausanne | Multiple wavelength neuron tomography by Digital Holographic Microscopy. | Digital Holographic Microscopy (DHM). | ||
| Sandor Kasas | BMI, EPFL, Lausanne | Study of the mechanical properties of neurons by atomic force microscopy. | Atomic force microscopy (AFM). | Kis et al. 2002 Kasas et al. 2005 Laurent et al. 2005 |
|
| Jozsef Kiss Alexandre Dayer |
CMU, Univesity of Geneva | Cellular dynamic of neural progenitor cells: analysis of cell migration and neurite outgrowth. | Time-lapse video analysis, imaging of transplanted cells in tissue, fluorescent and confocal optics, electron microscopy. | Zhang et al. 2003 Zhang et al. 2003 |
|
| Christian Lüscher | CMU, Univesity of Geneva | Characterization of the morphology of dopamine neurons in the VTA. | 2Photon confocal line scanning microscope (Olympus Fluoview). | Cruz & Lüscher 2005 | |
| Pierre Magistretti Pierre Marquet |
BMI, EPFL, Lausanne | Study of the neuron-glial dynamics with digital holography microscopy. | Digital holographic microscopy (DHM), video fluorescence microscopy and electrophysiology. |
Rappaz et al. 2005 Marquet et al. 2005 |
|
| Christoph Michel | CMU/HUG, Univesity of Geneva | Mapping of brain electric activity by high density scalp and intracranial EEG in man and mice. | High-Resolution (256-channel) scalp EEG and ERP in man, multichannel epicranial EEG and EP in mice, transcranial magnetic stimulation combined with EEG in man, intracranial mutlichannel EEG in epileptic patients. |
Michel et al. 2004 Michel et al. 2001 |
|
| Michel Mühlethaler | CMU, Univesity of Geneva | Modulation of "sleep or wake promoting" neurons in vitro. | In vitro electrophysiological recordings in rat brain slices; pharmacology. | ||
| Dominique Muller | CMU, Univesity of Geneva | Confocal imaging of synaptic plasticity and turn-over. | Slice cultures preparation, biolistic transfection, extracellular recordings, single photon and two-photon imaging of spines, time-lapse imaging. | ||
| Micah Murray | CHUV, University of Lausanne | Multisensory Interactions and Parallel Pathways in Human Sensory-Cognitive Processing. | 160 Channel EEG, electrical neuroimaging and psychophysics. | De Santis et al. 2006 Murray et al. 2004 Ghazanfar & Schroeder 2006 Murray et al. 2006 |
|
| Carl Petersen | BMI, EPFL, Lausanne | 1. Study of the spatiotemporal dynamics of spontaneous and whisker-evoked activity in the neocortex of mice. 2. Imaging of transgenic mice expressing GFP in a subset of neurons. |
1. In vivo voltage-sensitive dye imaging in anesthetised mice. 2. In vivo two-photon imaging in anesthetised mice. |
Petersen et al. 2003 Ferezou et al. 2006 Margrie et al. 2003 Tachtenberg et al. 2002 |
|
| Sophie Schwartz | CMU, Univesity of Geneva | Neural plasticity and reactivation of memory traces during sleep as assessed by functional MRI and EEG in humans. | Intracranial EEG recordings (in patients), long-term scalp EEG recordings (in normal controls) and fMRI. | Stickgold 2005 Peigneux et al. 2004 Huber et al. 2004 Maquet et al. 2000 |
|
| Dimitri van de Ville | BIG, EPFL, Lausanne | Fractal analysis of anatomical and functional MR brain data. | MRI acquisition (anatomical and functional); Signal & image processing; Statistical analysis. This project requires a solid background in signal processing and programming. |
Iftekharuddin et al. 2003 | |
| Horst Vogel Ruud Hovius |
ISIC, EPFL, Lausanne | Structure and dynamics of membrane proteins and biophysical chemistry on surfaces. | Labelling of membrane proteins in life cells; Single molecule detection by fluorescence imaging; Single molecule detection by fluorescence correlation spectroscopy (FCS); Evaluation of single molecule data; Formation of (bio-)membranes on solid supports; Fluorescence imaging. | Vukojevic et al. 2005 Kim et al. 2003 FSC Introduction Jankevics et al. 2005 Pick et al. 2003 Wohland et al. 1999 |
|
| Patrik Vuilleumier | CMU, Univesity of Geneva | Functional neuroimaging of cognitive and emotional processing. | fMRI, EEG and behavioural tests. |
Vuilleumier et al. 2004 Vuilleumier et al. 2001 Peelen et al. 2006 Sander et al. 2006 Sander et al. 2006 |
